Physiological concentrations of retinoic acid can induce acute alterations in the expression of the enzyme tissue transglutaminase in cultured macrophages. The induction of this enzyme offers a probe to study the mechanism of retinoid action in both normal and leukemic cells.

This chapter contains section titled: Context: Irrelevant and Relevant Hume's Argument against Justified Belief in Miracles Explained Immortality References Further Reading.

This chapter contains sections titled: Abstract Introduction Truth Relativism Metaphysics of Truth Relativism Truth Relativism and the Scope Problem Truth Pluralism Example: Relative Moral Truth Conclusion References.

This chapter contains sections titled: Introduction Mixed Inferences and Mixed Compounds Alethic Pluralism as Functionalism More than One Logic? Conclusion.

In this engaging and spirited text, Michael Lynch argues that truth does matter, in both our personal and political lives. He explains that the growing cynicism over truth stems in large part from our confusion over what truth is.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Political Affections: Civic Participation and Moral Theology by Joshua HordernMichael P. JaycoxPolitical Affections: Civic Participation and Moral Theology By Joshua Hordern NEW YORK: OXFORD UNIVERSITY PRESS, 2013. 312 PP. $125.00Hordern asks his reader to consider that the decline of participatory democracy in Western societies may be ameliorated by a renewed appreciation of the role of emotions in politics. Creatively retrieving many elements of the Augustinian tradition, he argues (...) that the “evaluative intentionality” of emotions is an imperfect type of moral insight whereby human beings both participate in and conform themselves to the created “order of value” (40, 77). Although the power of sin profoundly destabilizes human inclinations, emotions can become stable moral guides through a process of “intersubjective verification” (81). Hordern claims that the epistemological capacities of socially stabilized emotions are substantial enough to enable the community to “participate in and evaluate the goods with which institutional practices are concerned, recognize the authority of those who promote the proper ends of those goods, and initiate common political reflection and deliberation” (142).Bringing these insights to bear upon his own political context, Hordern claims the “resentment,” “alienation,” and “disillusionment” that some British citizens feel toward the cosmopolitan project of the European Union stands as [End Page 213] evidence that “law which is not primarily rooted in the locality which it governs will run the risk of opposing the affections of the people” (22, 23, 242). Working from the premise that “local loves are the fertile soil in which more wide-ranging loves may grow,” Hordern champions “the politically beneficial possibilities of a limited ethnocentricity,” by which he means that emotions shared in smaller communities and within nation-states motivate citizens to attend to the common good most effectively (224, 240).Anticipating the objections to this proposal, Hordern assures his reader that the influence of Christianity upon democratic processes minimizes the negative effects of ethnocentric nationalism, such as the oppression of socially vulnerable groups. Insofar as Christian emotions participate uniquely in the transcendent order of values, the participation of this community in the temporal order would “disturb, renew, or correct patterns of social trust” (271) and provide “a critical standpoint whereby affections in all institutions may be described and assessed” (164).This reviewer shares some of Hordern’s general premises regarding the intelligence of emotions and their motivational potential in public life. By way of evaluation, however, I find three significant problems with his argument. First, although Hordern grasps Martha Nussbaum’s emotion theory quite well, he habitually mischaracterizes the more central aspects of her moral thought in order to prop up his somewhat more conservative agenda. For example, he accuses her of denying the existence of a “stable moral order” and of endorsing an individualistic concept of agency (98). These inferences fail to account for the highly social and essentialist vision of human flourishing that provides the normative content of her capability theory and her feminist ethic.Second, he offers some weak arguments as he develops his account of emotional stabilization. For example, he alleges that virtue cannot stabilize emotion because it is a form of “epistemological self-dependence” that “tends to block repentant attentiveness,” but this assertion is grounded in his antecedent concern to discredit Aristotelian habituation as a moral theory (110, 101). As he develops his own alternative proposal about intersubjective verification by appeals to “the power of memory,” he glosses over significant counterarguments concerning the “contested” nature of social memories of historical events (110, 115).Third, Hordern does not propose any universal norms of justice capable of checking the authority of particular civil governments. For example, he seems dismissive about the moral dangers of emotionally motivated nationalism, the gravity of which he attempts to minimize by emphasizing the critical aspect of Christian political participation. (The historical record of fascism in Europe would hardly support such a claim.) Nevertheless, he presumes a tacit normative point of reference every time he offers a political judgment. For example, he claims that civil authority should caution “against overreaching [End Page 214] itself in pride,” but this is to beg the question of what the interventionist role of governments should be vis-à-vis systemic injustice (198).Political... (shrink)

In light of the structural dangers of revolutionary change highlighted in the political theory of Giorgio Agamben, this book joins a lively debate in philosophy of education on weak utopianism as an approach that foregrounds and respects the educational potentiality of teachers and students. Utopian moves in education call for revolutionary changes in pedagogical practice in pursuit of a particular vision of the good. Whether grounded in emancipatory politics, technological enthusiasm, or another social movement, utopian moves are seductive in their (...) promise of a better alternative. Weak Utopianism in Education draws together philosophy of education, political theory, scholarship of teaching and learning research, and utopian thought to advocate for a modest and humble approach to change. The theoretical foundation of weak utopianism opens space for educator's personal convictions and teaching philosophies to tinker with their own pedagogical practices. The book creates a common conceptual meeting ground for philosophers and practitioners in education. (shrink)

Merleau-Ponty and Buddhism explores a new mode of philosophizing through a comparative study of Maurice Merleau-Ponty's phenomenology and philosophies of major Buddhist thinkers including Nagarjuna, Chinul, Dogen, Shinran, and Nishida Kitaro. The book offers an intercultural philosophy in which opposites intermingle in a chiasmic relationship, and which brings new understanding regarding the self and the self's relation with others in a globalized and multicultural world.

The totalizing and absolutizing tendencies of metaphysics can undermine our essential ethical relationality. Is there a metaphysics that is robust enough and conducive to preserving this intuition? In answer, this paper will draw upon Martin Buber and Justus Buchler. Buber’s seminal work, I and Thou, explores the nature of the ethical encounter. Buchler’s Metaphysics of Natural Complexes develops a general ontology, which can be described as an ordinal metaphysics. Encounters are thoroughly relational for Buber. Buchler’s metaphysics is also thoroughly relational. (...) A phenomenological approach to relationality establishes the medium for this dialogue and provides a common ground for these texts. Not only is there a way to account for Buber’s encounter, but there is also an inherent moral understanding in Buchler’s metaphysics that preserves and is conducive to ethical relationality. Buchler’s metaphysics avoids the totalizing and absolutizing tendencies derided by Buber, while simultaneously promotes a version of the encounter. (shrink)

At the heart of this essay lies the problem of Christian universals.Sin-talk is arguably Christian theology’s primary contribution to any account of the human condition. Fashionable or unfashionabl...

Janna Thompson dismisses environmental ethics primarily because it does not meet her criteria for ethics: consistency, non-vacuity, and decidability. In place of a more expansive environmental ethic, she proposes to limit moral considerability to beings with a “point of view.” I contend, first, that a point-of-view centered ethic is unacceptable not only because it fails to meet the tests of her own and other criteria,but also because it is precisely the type of ethic that has contributed to our current environmental (...) dilemmas. Second, I argue that the holistic, ecocentric land ethic of Aldo Leopold, as developed by J. Baird Callicott, an environmental ethic that Thompson never considers, nicely meets Thompson’s criteria for acceptable ethics, and may indeed be the cure for our environmental woes. (shrink)

Those who in the past tended to say that being is a genus, coupled their assertion with the belief that the genus is univocal, thus making being univocal—a position which can easily be overturned. Others failed to distinguish between being as meaning essence, and so divisible into the ten categories, and being as meaning existence. The consequence was that they restricted the Divine Being to a genus of being, thereby denying God’s transcendence. As far as I know, the theory which (...) combines the two doctrines that the genus is analogical and that the being which is held to be a genus is only essence, has never been propounded. It merits investigation. (shrink)

"Readers intimidated or puzzled by Voegelin's often daunting prose will find Federici's volume, the fourth entry in ISI's Library of Modern Thinkers series, an invaluable guide to one of the twentieth century's most imposing - and most impressive - philosophical minds."--BOOK JACKET.

Devoted to the whole of Hamilton’s political writing, this accessible and teachable analysis makes clear the enormous influence Hamilton had on the development of American political and economic institutions and policies.

This paper addresses some of Sellars's views on conceptual change and revision, spread across several books and articles. It begins with Sellars's distinction between rules of criticism and rules of action. I argue that Sellars's distinction here actually sheds light on the epistemology of theoretical revision. Many revisions of theoretical commitments can be motivated by the force of rules of action that govern the maintenance of our theories. I offer a partial account of this, positing two rules of action. A (...) rule of maximizing explanatory strength compels us to refine and revise theories to improve their performance, while a rule of conservatism puts boundaries on the acceptable pursuit of those goals. The dynamic between these two guides revision, narrowing the range of acceptable options. Sellars's conception of the roles of analogy and affinity are considered, as well as an elaboration of a Sellarsian point about meaning change. (shrink)

Those who claim the concept of enlightenment (nibānna) has not evolved must rest their claim on a strong distinction between changing and variant interpretations of the concept on the one hand, and what the term really means or refers to on the other. This paper examines whether all evolution of the concept of enlightenment is best seen as interpretive variation rather than as embodying real notional change - a change in the reference of the term. It is implausible to suppose (...) that the enlightenment has not evolved, and also implausible to suppose that the notion of enlightenment is the same across various sects of Buddhism. Zen enlightenment is not the same as Theravada enlightenment. Two points of controversy about nibnna are discussed and Christian attitudes toward scripture are compared with those in Buddhism. (shrink)

Research on neural transplantation has great potential societal importance in part because of the expanding proportion of the population that is elderly. Transplantation studies can benefit from the guidance of research on cognitive aging, especially in connection with the assessment of behavioral outcomes. Speech for example, might be explored using avian models.

The debate concerning whether to legalize and regulate the global market in human organs is hindered by a lack of adequate bioethical language. The author argues that the preferential option for the poor, a theological category, can provide the grounding for an inductive moral epistemology adequate for reforming the use of culturally Western bioethical language. He proposes that the traditional, Western concept of bioethical coercion ought to be modified and expanded because the conditions of the market system, as viewed from (...) the perspective of organ vendors systemically deprived of access to sufficient resources, are sufficiently exploitative as to diminish the possibility of these vendors giving informed consent. Moreover, empirical studies conducted by professionals in medicine, sociology, psychiatry, economics, and medical anthropology continue to contribute support to the growing interdisciplinary consensus that functionally coercive structural factors exert the most significant influence upon a vendor's decision to sell an organ within any market, regardless of legality or degree of regulation. Therefore any proposal to legalize and regulate the organ market remains patently unethical because doing so would likely function to constrain further the agency of poor potential vendors. (shrink)

In December’s Quadrant James Franklin asked “Is Jensenism compatible with Christianity?” and claimed of Sydney Anglicans that they “fear the gospels, for the gospel message is inconvenient”. This brand of “narrow” “Bible-based” Christianity pits Paul against Jesus, he says; engages in selective reading of the Bible; and creates “an inwardlooking and recent sect.”.

Introduces Christians to the thought of St. Thomas Aquinas, equipping them to apply their faith to the complex moral, economic, and political problems of contemporary society.

From sense to reason: a genetic account -- Reasoning to the body politic -- Reasoning in the body politic -- Dominated by the passions: irrationality and the prideful individual -- The moralization of pride -- Taming curiosity: the commonwealth's philosopher -- The desire for divinity: spiritual pride in the commonwealth.

The shift from the logical to the empirical argument from evil against the existence of God has been seen as a victory by analytic philosophers of religion who now seek to establish that the existence of evil fails to make the existence of God improbable. I examine several arguments in an effort to establish the following: (i) Their victory is pyrrhic. They distort the historical, philosophical and religious nature of the problem of evil. (ii) In attempting to refute the empirical (...) argument they rely on disguised but well-worn strategies. (iii) A refusal to let evil count in any way against the probability of the existence of God indicates that their rejection is ideological and contrary to traditional theism. (iv) Aspects of their arguments are morally repugnant. (v) Their arguments are indicative of a lack of vitality, relevance and “seriousness” in Christian analytic philosophy of religion. (shrink)

An investigation into the way in which information technology has shaped how and what we know, from "Google-knowing" to privacy and social media.

After reflecting on his own undergraduate education, when the study of Newman’s The Idea of a University led to a transformation of his view of education and even life itself, Michael Krom discusses—in the contemplative spirit that Newman contended to be the purpose of education—how Newman’s Idea can be taught in a way so that today’s students are enlivened with the universal call to Truth and Holiness.